The short answer is YES, very definitely. God has created each one of us with the power of free choice, and we can at any time reject the Holy Spirit and the free gift of God’s grace. God does not force anyone, so it depends on us and how we choose. Let’s look at some Bible passages.

Hebrews 10     ²⁶ For if we sin willfully after we have received the knowledge of the truth, there no longer remains a sacrifice for sins, ²⁷ but a certain fearful expectation of judgment, and fiery indignation which will devour the adversaries. ²⁸ Anyone who has rejected Moses’ law dies without mercy on the testimony of two or three witnesses. ²⁹ Of how much worse punishment, do you suppose, will he be thought worthy who has trampled the Son of God underfoot, counted the blood of the covenant by which he was sanctified a common thing, and insulted the Spirit of grace?

Luke 8:13    “But the ones on the rock are those who, when they hear, receive the word with joy; and these have no root, who believe for a while and in time of temptation fall away.”

Hebrews 6     ⁴ For it is impossible for those who were once enlightened, and have tasted the heavenly gift, and have become partakers of the Holy Spirit, ⁵ and have tasted the good word of God and the powers of the age to come, ⁶ if they fall away, to renew them again to repentance, since they crucify again for themselves the Son of God, and put Him to an open shame.

Ezekiel 3     ²⁰ “Again, when a righteous man turns from his righteousness and commits iniquity, and I lay a stumbling block before him, he shall die; because you did not give him warning, he shall die in his sin, and his righteousness which he has done shall not be remembered; but his blood I will require at your hand. ²¹Nevertheless if you warn the righteous man that the righteous should not sin, and he does not sin, he shall surely live because he took warning; also you will have delivered your soul.”

Ezekiel 33:18    When the righteous turns from his righteousness and commits iniquity, he shall die because of it.

1 Timothy 4      Now the Spirit expressly says that in latter times some will depart from the faith, giving heed to deceiving spirits and doctrines of demons, ² speaking lies in hypocrisy, having their own conscience seared with a hot iron,

2 Peter 2     ²⁰ For if, after they have escaped the pollutions of the world through the knowledge of the Lord and Savior Jesus Christ, they are again entangled in them and overcome, the latter end is worse for them than the beginning. ²¹ For it would have been better for them not to have known the way of righteousness, than having known it, to turn from the holy commandment delivered to them.

Let’s now look at an example from the Bible, of King Saul, who at the beginning was filled with the Holy Spirit, and yet ended up far away from God, and ended his own life.

1 Samuel 10     ⁶ “Then the Spirit of the LORD will come upon you, and you will prophesy with them and be turned into another man.”

⁹ So it was, when he had turned his back to go from Samuel, that God gave him another heart; and all those signs came to pass that day. ¹⁰ When they came there to the hill, there was a group of prophets to meet him; then the Spirit of God came upon him, and he prophesied among them.

1 Samuel 15     ¹⁰ Now the word of the LORD came to Samuel, saying, ¹¹ “I greatly regret that I have set up Saul as king, for he has turned back from following Me, and has not performed My commandments.”

1 Samuel 28     ⁵ When Saul saw the army of the Philistines, he was afraid, and his heart trembled greatly. ⁶ And when Saul inquired of the LORD, the LORD did not answer him, either by dreams or by Urim or by the prophets.

1 Chronicles 10:4   Then Saul said to his armorbearer, “Draw your sword, and thrust me through with it, lest these uncircumcised men come and abuse me.” But his armorbearer would not, for he was greatly afraid. Therefore Saul took a sword and fell on it.

And finally, let us look at some of the warnings given by God to the church, in which it was stated that the devil would pull people away from Him.

Acts 20     ²⁸ “Therefore take heed to yourselves and to all the flock, among which the Holy Spirit has made you overseers, to shepherd the church of God which He purchased with His own blood. ²⁹ For I know this, that after my departure savage wolves will come in among you, not sparing the flock. ³⁰ Also from among yourselves men will rise up, speaking perverse things, to draw away the disciples after themselves.”

2 Peter 2      ¹ But there were also false prophets among the people, even as there will be false teachers among you, who will secretly bring in destructive heresies, even denying the Lord who bought them, and bring on themselves swift destruction.

² And many will follow their destructive ways, because of whom the way of truth will be blasphemed. ³ By covetousness they will exploit you with deceptive words; for a long time their judgment has not been idle, and their destruction does not slumber.

I trust that this makes sense to you. God bless!